1997 PhD - King's College London, London
1992 BSc Pharmacology (Hons) - University of Portsmouth
After completing his PhD Vinood continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD.
His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation.
Awards and Grants
2006 Awarded UoW PhD research scholarship.
2007 Awarded UoW Cavendish PhD scholarship.
2007 Wellcome Student Scholarship and Nuffield Foundation Scholarship 1997-2003 Supported by National Institute on Alcohol Abuse and Alcoholism (NIAAA).
2013 Saudi Arabian Government PhD scholarship
Course leader for MSc Biomedical Sciences (Clinical Biochemistry)
Module leader for Applied Pathophysiology and Diagnostic Clinical Biochemistry
Alcoholic liver disease is the most prevalent liver disease in the Western world and the leading cause of liver cirrhosis. The prognosis for both severe alcoholic hepatitis and cirrhosis is poor with a death rate of up to 50%.
Therefore it is important to understand the early events/key changes arising in the pathogenesis of ALD. The precise mechanisms responsible for ALD are poorly understood, however a number of key events are clearly involved, which we are studying. These include altered mitochondrial function, oxidative stress, acetaldehyde toxicity and nutritional deprivation/abnormal antioxidant regulation.
One area related to the above alterations involves understanding the consequences of oxidative stress. Continued alcohol metabolism results in an alteration to the cellular redox state, due to an increase in the reducing equivalent NADH. This imbalance has an immediate effect on corresponding metabolic pathways, such as the TCA cycle and fatty acid metabolism. However, the high levels of NADH are also utilised in the oxidative phosphorylation system, causing increased flux of electron transport, which results in leakage of reactive oxygen species (ROS). Some of the consequences of ROS tissue injury have been determined, such as lipid peroxidation however, ROS involvement in cell death, particularly apoptotic cell death remains to be elucidated. Increased cell death, whether by necrosis or apoptosis is thought to be a prominent factor in the development of ALD.
Current Research / Ongoing Projects
Current Research The extent of cell death via apoptosis in ALD has not been fully characterised.One of the key questions to be addressed includes determining physiological and patho-physiological apoptotic cell death due to alcohol and related agents. We also aim to assess whether alterations to metabolic pathways correlate with cell death and we are also investigating agents that can ameliorate apoptotic cell death. Other areas include identifying aldehyde-protein adducts and their impact on cellular function. To elucidate these problems we are using both in vitro and in vivo models of ALD and using a wide range of the latest techniques to determine apoptosis.
Another major area of study involves investigating the mechanism involved in the development of fatty liver disease due to the consumption of dietary fatty acids. These investigations involve examining pathways involved in lipid accumulation, cell death, as well as mitochondrial function.
- Ongoing Projects Mechanisms of apoptosis in alcoholic liver disease.
- Nutritional intervention in alcoholic liver disease.
- Post-translational modification of proteins.
- Cellular interactions between hepatic cells.
- Biomarkers of hepatic toxicity.
- Hepatic iron overload.
- Fatty Liver Disease
Membership of Professional Bodies
British Association for the study of the Liver (BASL); European Association for the study of the Liver (EASL); Royal Society of Chemistry;
For details of all my research outputs, visit my WestminsterResearch profile.