Dr Sarah Coleman

Lecturer in biochemistry

+44 20 7911 5000 ext 64862
115 New Cavendish Street London W1W 6UW

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I read for a BSc (Hons) (1989) in Biochemistry at University of Essex; then for a PhD (1996) in Biochemistry at the School of Pharmacy, University of London under Prof. F. Anne Stephenson. There I examined the pharmacological and biochemical properties of NMDA receptors, a sub-family of ionotropic glutamate receptors. The title of my thesis being NMDA receptors: A Biochemical Characterization. Following this I had a brief stint at Imperial College, London examining potassium channels combinations in the brain.

I moved to Helsinki, Finland and entered the Department of Biosciences, University of Helsinki. Where I joined the Glutamate Receptor group of Professor Kari Keinänen examining AMPA receptors (another sub-family of the ionotropic glutamate receptors) their biogenesis, assembly and trafficking. In 2010 I became a Docent in Biochemistry and a University Researcher at the University of Helsinki.

In November 2015 I joined the Department of Life Science, University of Westminster as a lecturer in Biochemistry.

I am a member of The Biochemical Society (UK), British Neuroscience Association and The Society for Neuroscience (USA).

Module leader for: Level 4 Biochemistry 4BICH001W

Teaching on: 4BICH003W Science History and Philosophy and Practice; 6BICH002W Proteins and Enzymes; 6BIOL002W Advanced Cell Biology

Involved and teaching on with the University cross discipline elective (MAD and FST) Art / Science Collaboration 5WSEL001W

Involved with the University of Westminster iGEM team 2017

My research is focused on the assembly and molecular interactions of the ionotropic glutamate receptors, especially the AMPA receptor subtype and their associated proteins. AMPA receptors are tetrameric glutamate-gated cation channels and are the primary mediators of fast excitatory neurotransmission. They are fundamental for normal synaptic physiology and memory formation; they are also involved in a number of common neurological disorders, for example; intellectual disability, autism spectrum disorders, Alzheimer’s disease and schizophrenia. The receptors are composed from homologous subunits, GluA1 to A4, (generated from genes Gria1-4).

 I have focused on the inherent logic of AMPA receptor assembly and trafficking; the ability of AMPA receptor subunits to associate with each other and to make a correctly localized and functional receptor in the absence of external factors, which may normally be present (in the neuron). My research has centred upon the biogenesis of AMPA receptors, i.e. from polypepetide production in the endoplasmic reticulum (ER), their assembly (via dimers, then as tetramers) through to the ER exit of the correctly folded and assembled receptors (early trafficking). Thus, the vital role of the extracellular ligand-binding domain in AMPA receptor quality control processes was demonstrated in a series of studies. Currently, I am examining the difference in trafficking behaviour of the native GluA2 vs GluA3, also including the stability and aggregation phenotypes of the respective homomeric receptors. 

http://orcid.org/0000-0002-1066-8296

http://www.researchgate.net/profile/Sarah_Coleman5

2017

Using virtual reality to prepare Bioscience students for practical classes (2017)
Coleman, S.K., Volpi, E. and Smith, C.L. 2017. Using virtual reality to prepare Bioscience students for practical classes. 16th Westminster Symposium Innovate!. University of Westminster, London 22 to end of 22 Jun 2017
Increasing accessibility of students to laboratory classes through the use of Virtual laboratory simulations (2017)
Smith, C.L. and Coleman, S.K. 2017. Increasing accessibility of students to laboratory classes through the use of Virtual laboratory simulations . UALL Work and Learning Network Annual Conference 2017 - Leading the Way: Shaping Practice in the Workplace and the Academy.. Middlesex University 23 to end of 23 Jun 2017
Using Labster to improve Bioscience student learning and engagement in practical classes (2017)
Smith, C.L. and Coleman, S.K. 2017. Using Labster to improve Bioscience student learning and engagement in practical classes. Heads of Biological Sciences, Royal Society of Biology. Spring 2017 meeting.. University of Leicester 10 to end of 11 May 2017

2016

Art Science Collaboration: Life in a New Light (2016)
Smith, R.A.J., Coleman, S.K. and Ramashye, P. 2016. Art Science Collaboration: Life in a New Light. Creativity in Science Teaching, Society of Experimental Biology. Charles Darwin House, London, UK 12 to end of 14 Dec 2016

2017

Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors (2017)
von Ossowski, L., Li, L-L., Moykkynen, T., Coleman, S.K., Courtney, M.J. and Keinänen, K. 2017. Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors. PLoS One. 12 (2), p. e0171489.
Molecular mechanisms controlling synaptic recruitment of GluA4 subunit-containing AMPAreceptors (2017)
Luchkina, N.V., Coleman, S.K., Huupponen, J., Cai, C., Kivisto, A., Taira, T., Keinanen, K. and Lauri, S.E. 2017. Molecular mechanisms controlling synaptic recruitment of GluA4 subunit-containing AMPAreceptors. Neuropharmacology. 112 (Part A), pp. 46-56.

2016

Aggregation Limits Surface Expression of Homomeric GluA3 Receptors (2016)
Coleman, S.K., Hou, Y., Willibald, M., Semenov, A., Moykkynen, T. and Keinänen, K. 2016. Aggregation Limits Surface Expression of Homomeric GluA3 Receptors. Journal of Biological Chemistry. 291, pp. 8784-8794.

2014

The N-terminal domain modulates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor desensitization (2014)
Moykkynen, T., Coleman, S.K., Semenov, A. and Keinänen, K. 2014. The N-terminal domain modulates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor desensitization. Journal of Biological Chemistry. 289 (19), pp. 13197-13205.
Developmental switch in the kinase dependency of long-term potentiation depends on expression of GluA4 subunit-containing AMPA receptors (2014)
Luchkina, N.V., Huupponen, J., Clarke, V.R., Coleman, S.K., Keinänen, K., Taira, T. and Lauri, S.E. 2014. Developmental switch in the kinase dependency of long-term potentiation depends on expression of GluA4 subunit-containing AMPA receptors. Proceedings of the National Academy of Sciences of the United States of America. 111 (11), p. 4321–4326.

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