About the group
The Pathobiology and Extracellular Vesicles research group, within the Research Centre for Resilience, is based in the University of Westminster's School of Life Sciences. The research group aims to unravel the interplay of innate, adaptive, and epigenetic contribution to pathobiological processes, leading to the identification of novel molecular targets and therapies to improve human health during their lifespan and to expand our understanding of the One Health concept.
Projects and initiatives
Find out about the funded projects undertaken by the Pathobiology and Extracellular Vesicles research group
Publications
Pathobiology and Extracellular Vesicles' recent publications include:
- Smith GR, Uysal-Onganer P, Kraev I, van Breukelen F, Lange S. Immune Tuning in Extreme Environments: Protein Citrullinome and Extracellular Vesicle Signatures Comparing Hibernating Versus Active States in the Heterothermic and Heterometabolic Tenrec (Tenrec ecaudatus). Biology (Basel). 2025, 14(8):1056.
- D'Alessio S, Kraev I, Magnadóttir B, Lange S. Exploring the Potential of Extracellular Vesicles from Atlantic Cod (Gadus morhua L.) Serum and Mucus for Wound Healing In Vitro. Biology (Basel). 2025, 14(7):870.
- Vaughan OR, Maksym K, Hillman S, Spencer RN, Hristova M, David AL, Lange S. Placental Protein Citrullination Signatures Are Modified in Early- and Late-Onset Fetal Growth Restriction. Int J Mol Sci. 2025, 26(9):4247.
- Lange S, Bernstein DE, Dimov N, Puttaswamy S, Johnston I, Kraev I, Needham SR, Vasdev N, Inal JM. Urinary Extracellular Vesicle Signatures as Biomarkers in Prostate Cancer Patients. Int J Mol Sci. 2025, 26(14):6895.
- Santos M, Bukhari K, Peker-Eyüboğlu I, Kraev I, Dart DA, Lange S, Uysal-Onganer P. Hypoxia-Driven Extracellular Vesicles Promote Pro-Metastatic Signalling in LNCaP Cells via Wnt and EMT Pathways. Biology. 2025, 14(9):1135.
- Yerramalli, S., Getting, S.J., Kyazze, G. and Keshavarz, T. 2025. The Role of Quorum Sensing in Enhancing Lovastatin and Pigment Production in Monascus purpureus C322. Fermentation. 11 (8) 461.
- Ramos-Sevillano, Elisa, Ercoli, Giuseppe, Betts, Modupeh, Guerra-Assunção, José Afonso, Iverson, Amy, Frank, Matthew, Partridge, Frederick, Lo, Stephanie W., Fernandes, Vitor E., Nasher, Fauzy, Wall, Emma, Wren, Brendan, Gordon, Stephen B., Ferreira, Daniela M., Heyderman, Rob, Rosch, Jason and Brown, Jeremy S. 2024. Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of Streptococcus pneumoniae. mBio. 15 (11), pp. e01758-24.
People
Head of Group: