Pathobiology and Extracellular Vesicles Research Group | University of Westminster

About the group

The Pathobiology and Extracellular Vesicles research group, within the Research Centre for Resilience, is based in the University of Westminster's School of Life Sciences. The research group aims to unravel the interplay of innate, adaptive, and epigenetic contribution to pathobiological processes, leading to the identification of novel molecular targets and therapies to improve human health during their lifespan and to expand our understanding of the One Health concept.

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Projects and initiatives

Find out about the funded projects undertaken by the Pathobiology and Extracellular Vesicles research group

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Publications

Pathobiology and Extracellular Vesicles' recent publications include:

Needham SR, Davis BM, Uysal-Onganer P, Rolfe DJ, Hristova M, Kraev I, Inal JM, Lange S. Profiling Protein Citrullination in Extracellular Vesicles by Single-Molecule Detection Using Direct Stochastic Optical Reconstruction Microscopy. J Biophotonics. 2025, e202500483
Mannaperuma D, Stratton D, Lange S, Inal JM. Extracellular Vesicles from the Myocyte Secretome Contribute In Vitro to Creating an Unfavourable Environment for Migrating Lung Carcinoma Cells. Biology (Basel). 2025;14(11):1578.
Smith GR, Uysal-Onganer P, Kraev I, van Breukelen F, Lange S. Immune Tuning in Extreme Environments: Protein Citrullinome and Extracellular Vesicle Signatures Comparing Hibernating Versus Active States in the Heterothermic and Heterometabolic Tenrec (Tenrec ecaudatus). Biology (Basel). 2025, 14(8):1056.
D'Alessio S, Kraev I, Magnadóttir B, Lange S. Exploring the Potential of Extracellular Vesicles from Atlantic Cod (Gadus morhua L.) Serum and Mucus for Wound Healing In Vitro. Biology (Basel). 2025, 14(7):870.
Vaughan OR, Maksym K, Hillman S, Spencer RN, Hristova M, David AL, Lange S. Placental Protein Citrullination Signatures Are Modified in Early- and Late-Onset Fetal Growth Restriction. Int J Mol Sci. 2025, 26(9):4247.
Lange S, Bernstein DE, Dimov N, Puttaswamy S, Johnston I, Kraev I, Needham SR, Vasdev N, Inal JM. Urinary Extracellular Vesicle Signatures as Biomarkers in Prostate Cancer Patients. Int J Mol Sci. 2025, 26(14):6895.
Santos M, Bukhari K, Peker-Eyüboğlu I, Kraev I, Dart DA, Lange S, Uysal-Onganer P. Hypoxia-Driven Extracellular Vesicles Promote Pro-Metastatic Signalling in LNCaP Cells via Wnt and EMT Pathways. Biology. 2025, 14(9):1135.

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People

Head of Group:

Professor Sigrun Lange - Professor

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Our location

The Pathobiology and Extracellular Vesicles research group is part of the Research Centre for Optimal Health, located within the University of Westminster’s School of Life Sciences, 115 New Cavendish Street, London W1W 6UW.