Pathobiology and Extracellular Vesicles Research Group | University of Westminster

About the group

The Pathobiology and Extracellular Vesicles research group, within the Research Centre for Resilience, is based in the University of Westminster's School of Life Sciences. The research group aims to unravel the interplay of innate, adaptive, and epigenetic contribution to pathobiological processes, leading to the identification of novel molecular targets and therapies to improve human health during their lifespan and to expand our understanding of the One Health concept.

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Projects and initiatives

Find out about the funded projects undertaken by the Pathobiology and Extracellular Vesicles research group

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Publications

Pathobiology and Extracellular Vesicles' recent publications include:

Ahmed, D., Getting, S. J., Ashioti, M., & Lange, S. (2026). Targeting Peptidylarginine Deiminases in Neurons and Astrocytes in Central Nervous System Injury—Effects of Pan-PAD Inhibitor Cl-Amidine in an Oxygen–Glucose Deprivation Model of Ischaemia (OGD/R) and LPS Stimulation In Vitro. International Journal of Molecular Sciences, 27(11), 5118.
Thiyagarajan, D.B., Mikkelborg, M.K., Kraev, I., Dalmo, R.A. and Lange, S. 2026. Characterization of extracellular vesicles from primary skin epithelial cells and cell lines from Atlantic salmon. Developmental and Comparative Immunology. 176 105555
Li R, Needham SR., Kraev I, Hristova M and Lange S (2025) Extracellular vesicle signatures from eye lavage as novel non-invasive biomarkers for hypoxic ischaemic insult—findings from a neonatal mouse model. Front. Med. Technol. 7:1715676. doi: 10.3389/fmedt.2025.1715676
Needham SR, Davis BM, Uysal-Onganer P, Rolfe DJ, Hristova M, Kraev I, Inal JM, Lange S. Profiling Protein Citrullination in Extracellular Vesicles by Single-Molecule Detection Using Direct Stochastic Optical Reconstruction Microscopy. J Biophotonics. 2025, e202500483
Mannaperuma D, Stratton D, Lange S, Inal JM. Extracellular Vesicles from the Myocyte Secretome Contribute In Vitro to Creating an Unfavourable Environment for Migrating Lung Carcinoma Cells. Biology (Basel). 2025;14(11):1578.

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People

Head of Group:

Professor Sigrun Lange - Professor

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Our location

The Pathobiology and Extracellular Vesicles research group is part of the Research Centre for Optimal Health, located within the University of Westminster’s School of Life Sciences, 115 New Cavendish Street, London W1W 6UW.