The new collaborative research revealed a combination of genes that are linked to higher BMI but paradoxically protect people from developing Type-2 diabetes and heart disease.
It appears that despite the increased BMI, these participants show a favourable fat distribution such as increased superficial body fat (subcutaneous) but significantly lower deleterious internal fat (visceral and liver).
The study, recently published in the renowned scientific journal Diabetes, included measurements of body fat and liver fat content recorded through magnetic resonance imaging (MRI) and in combination with individual DNA profiles.
The data from the UK Biobank and several other large pan-European cohorts of patients showed 14 genetic variations which were linked with increased overall fatness, but a lower risk of disease due to where people actually carry their excess fat.
Talking about the research, Dr Louise Thomas explained: “This work suggests a genetic basis which may explain why some people may be metabolically healthy despite being obese and conversely why others, even though being normal weight, have a greater risk of developing conditions such as type-2 diabetes and cardiovascular disease due to storing their fat in the wrong places.”