It is well understood that human ageing involves a general loss of organ function, including muscle strength and size, from about 30 years of age. Whilst there are several theories as to why people grow older, it is not well understood how and why this occurs. This publication revealed blood from younger and older people show differences in hormones that control the growth of muscle cells. Importantly, if muscle cells were grown in blood from younger and older people, the cells grown in older blood showed ageing-like responses relative to the cells grown in younger blood. Candidate hormones that may cause these differences were also identified and described.
Ms Kalampouka stated that "Research and past publications related to ageing - both physiological and molecular - has awakened an interest to answer these fundamental questions. I couldn't feel more honoured that the research paper was accepted for publication. This is the culmination of my academic training, and I now believe that I belong in a research field". Dr Bradley Elliott, senior author of this paper and Ms Kalampouka's research supervisor said "this paper represents a significant and impressive body of work that Ifigeneia completed during her Masters, and provides an intriguing observation on the endocrine factors that contribute to the loss of function in muscle with age".
Dr Elliott's research at the University of Westminster examines the physiology of human ageing, including the mechanisms that control the loss of muscle function, mass and health throughout adulthood, and importantly, how to prevent this.
The full reference for this article is:
Kalampouka, I., van Bekhoven, A. & Elliott, BT. (2018). Differing Effects of Younger and Older Human Plasma on C2C12 Myocytes in vitro. Front. Physiol., 9. https://doi.org/10.3389/fphys.2018.00152