Tissue Architecture and Regeneration Research Group
Dr Sigrun Lange – Project Leader
Peptidylarginine deiminases (PADs) in tissue regeneration and extracellular vesicle modulation
- We have shown that PAD mediated protein deimination is crucial in central nervous system damage, and that pharmacological inhibition of PADs promotes tissue regeneration. We are currently working towards PAD modulatory treatments in models of CNS regeneration.
- We have demonstrated a novel role for PADs in extracellular vesicle biogenesis in several types of cancer. This is highly relevant for novel treatment possibilities in a number of pathologies. Our studies on extracellular vesicle manipulation in cancer and regeneration are ongoing.
- We are interested in the role of PADs in neurodegenerative disease progression, particularly with respect to neuroinflammatory responses and extracellular vesicle release. We are currently investigating PADs in models of Alzheimer’s disease, Parkinson ’s disease, frontotemporal dementia and amyotrophic lateral sclerosis.
- We foster interdisciplinary, national and international collaborations including with research groups at UCL Institute of Neurology (Dr S Wray, Prof J Hardy, Prof F Edwards, Dr M Devine, Dr J Pocock), UCL Institute for Women’s Health (Dr M Hristova), The University of Hertfordshire (Prof J Inal), The University of Alabama School of Medicine (Prof AP Nicholas) and the UMass Medical School (Prof P Thompson).