Research Centre for Optimal Health



Thomas EL, Parkinson JR, Frost G, Goldstone AP, McCarthy J, Collins A, Fitzpatrick J, Durighel G, Taylor-Robinson SD, Bell1 JD. The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat. Obesity 2012; 20:76-87
Watson A, Pride N, Thomas EL., Ind P, Bell JD. Relation between trunk fat volume and reduction of total lung capacity in obese men. J Appl Physiol 2012; 112:118-26
Hankir MK, Parkinson JR, Bloom SR, Bell JD. The Effect of Peripheral Administration of Glutamate Receptor Agonists and Antagonists on Mouse Hypothalamic Neuronal Activity Shown through Manganese Enhanced MRI. J Neurochem 2012; 59:968-78
Hankir M, Bueter M, Gsell W, Khalil M, Smith K, Bloom SR, Bell JD, Leroux C. Increased Energy Expenditure in Gastric Bypass Rats Is Not Caused by Activated Brown Adipose Tissue. Obes Fact 2012; 5:349–358
Mehta SR, Godsland IF, Thomas EL, Pavitt DV, Morin SX, Bell JD, Taylor-Robinson SD, Johnston DG. Intra-Hepatic Insulin Exposure, Intrahepatocellular Lipid and Regional Body Fat in Non-Alcoholic Fatty Liver Disease. J Clin Endocrinol Metab 2012; 97:2151-9
Gardner CJ, Irwin A, Daousi C, Macfarlane I, Joseph F, Bell JD, Thomas EL, Adams V, Kemp G, Cuthbertson DJ.  Non Alcoholic Fatty Liver Disease, growth hormone deficiency and the effects of growth hormone replacement: a LIVERpool magnetic resonance spectroscopy study. Eur J Endocrinol 2012; 166:993-1002
Pugh JAT, Cox AG, McLeod CW, Bunch J,  Writer MJ,  Hart SL, Bienemann A, White E, Bell JD. Elemental imaging of MRI contrast agents: benchmarking of LA-ICP-MS to MRI Anal Bioanal Chem 2012; 403:1641-9
Anastasovska J, Arora T, Sanchez Cañon GJ, Parkinson JRC, Ruey-Leng L, Tuohy K, Gibson GR, Nadkarni NA, So P-W, Goldstone AP, Thomas EL, Hankir MK, Van Loo J, Modi N, Bell JD. Fermentable Carbohydrate Alters Hypothalamic Neuronal Activity and Protects Against the Obesogenic Environment. Obesity 2012; 20:1016-23
Taylor AE, Kuper H, Varma RD, Wells JC, Bell JD, V Radhakrishna K, Kulkarni B, Kinra S, Timpson NJ, Ebrahim S, Smith GD, Ben-Shlomo Y. Validation of dual energy x-ray absorptiometry measures of abdominal fat by comparison with magnetic resonance imaging in an Indian population. PLoS One. 2012; 7:e51042
Jones H, Sprung VS, Pugh CJ, Daousi C, Irwin A, Aziz N, Adams VL, Thomas EL, Bell JD, Kemp GJ, Cuthbertson DJ. Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance. J Clin Endocrinol Metab 2012 ; 97:3709-16
Katzmarzyk PT, Shen W, Baxter-Jones A, Bell JD, Butte NF, Demerath EW, Gilsanz V, Goran MI, Hirschler V, Hu HH, Maffeis C, Malina RM, Müller MJ, Pietrobelli A, Wells JCK. Adiposity in children and adolescents: correlates and clinical consequences of fat stored in specific body depots. Ped Obesity 2012 ; 7:42-61
Arora T, Anastasovska J, Gibson G, Tuohy K, Ksharma R, Bell JD,  Frost G. Effect of L. acidophilus NCDC 13 supplementation on progression of obesity in diet induced obese mice. BJN 2012; 108: 1382–1389
Backhouse K, Sarac I, Shojaee-Moradie F, Stolinski M, Robertson MD, Frost GS, Bell JD, Thomas EL, Wright J, Russell-Jones D, Umpleby AM. Fatty acid flux and oxidation is increased by rimonabant in obese women. Metabolism 2012; 61:1220-3
Sarac I, Backhouse K, Shojaee-Moradie F, Stolinski1 M, Robertson MD, Bell JD, Thomas EL, Hovorka R, Wright J, Umpleby AM. Gender differences in VLDL1 and VLDL2 triglyceride kinetics and fatty acid kinetics in obese postmenopausal women and obese men. J Clin Endocrinol Metab 2012; 97:2475-81
Vasu V, Thomas EL, Durighel G, Hyde MJ, Bell JD, Modi N. Early nutritional determinants of intrahepatocellular lipid deposition in preterm infants at term age. Int J Obes 2013; 37:500-4
Forbes S, Godsland IF, Taylor-Robinson SD, Bell JD, Thomas EL, Patel N, Hamilton G, Parker KH, Marshall I, Gray CD, Bedford D, Caslake M, Walker BR, Johnston DG. A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid. Diabetologia 2013; 56:2021–2033
Anstee Q, Knapp S, Maguire E, Hosie A, Thomas P, Mortensen M, Bhome R, Martinez A, Walker S, Dixon C, Ruparelia K, Montagnese S, Kuo YT, Herlihy A, Bell JD, Robinson I, Guerrini I, McQuillin A, Fisher E, Ungless M, Gurling H, Morgan M, Brown S, Stephens D, Belelli D, Lambert J, Smart T, Thomas H. Mutations in the GABRB1 gene promote alcohol consumption through increased tonic inhibition. Nature Com  2013; 4:2816
Sung S, Holmes H, Wainwright L, Toscani A, Stasiuk GJ, White AJ, Bell JD, Wilton-Ely JD. Multimetallic Complexes and Functionalized Gold Nanoparticles Based on a Combination of d- and f-Elements. Inorg Chem 2014; 53:1989−2005
Goldstone AP, Prechtl CG, Scholtz S, Miras AD, Chhina N, Durighel G, Deliran SS, Beckmann C, Ghatei MA, Ashby D, Waldman AD, Gaylinn BD, Thorner MO, Frost GS, Bloom SR, Bell JD.  Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex and hippocampal responses to food. AJCN 2014; 99:1319-1330
Vasu V, Durighel G, Thomas EL, Malamateniou C, Bell JD, Rutherford MA, Modi N. Preterm nutritional intake and MRI phenotype at term age: a prospective observational study BMJ Open 2014; 4:e005390
Scholtz S, Miras AD, Chhina N, Prechtl CG, Sleeth M, Daud NM, Ismail N, Durighel D, Ahmed AR, Olbers T, Vincent RP, Alaghband-Zadeh J, Ghatei MA, Waldman AD, Frost GS, le Roux CW, Bell JD, Goldstone AP. Obese patients after gastric bypass surgery have healthier brain hedonic responses to food than after gastric banding. Gut 2014; 63:891-902
Gale C, Thomas EL, Jeffries S, Durighel G, Logan KM, Parkinson JRC, Uthaya S, Santhakumaran S, Bell JD, Modi N. Adiposity and hepatic lipid in healthy full term, breast-fed and formula-fed human infants: a prospective short-term longitudinal cohort study. AJCN 2014; 99:1034-40
Daud NM, Ismail NA, Thomas El, Fitzpatrick JA, Scholtz S, Bell JD, Swann JR, Costabile A, Childs CE, Pedersen C, Goldstone AP, Frost GS. The impact of oligofructose on stimulation of gut hormones, appetite regulation and body composition. Obesity 2014; 22:1430-8
Smith L, Thomas EL, Hamer M, Bell JD.  The association between objectively measured sitting and standing with body composition: A pilot study using magnetic resonance imaging. BMJ Open 2014; 4:e005476
Frost G, Sleeth ML, Arisoylu MA, Lizarbe B, Cerdan S, Brody L, Anastasovska J, Ghourab S, Hankir M, Zhang S, Carling D, Swan J, Gibson G, Viardot A, Morrison D, Thomas El, Bell JD. The short chain fatty acid acetate reduces appetite via a central homeostatic mechanism. Nature Com  2014; 5:3611
Nunn AVW, Guy GW, Bell JD. The intelligence paradox; will ET get the metabolic syndrome? Lessons from and for Earth. Nutrition & Metabolism 2014; 11:34-47
Cuthbertson DJ, Weickert MO, Lythgoe D, Sprung VS, Dobson R, Shoajee-Moradie F, Umpleby M, Pfeiffer AF, Thomas EL, Bell JD, Jones H, Kemp GJ. External validation of the fatty liver index and lipid accumulation product indices, using 1H-magnetic resonance spectroscopy, to identify hepatic steatosis in healthy controls and obese, insulin-resistant individuals. Eur J Endocrinol 2014; 171:561-9
Chambers ES, Viardot A, Psichas A, Morrison DJ, Murphy KG, Zac-Varghese SE, MacDougall K, Preston T, Tedford C, Finlayson GS, Blundell JE, Bell JD, Thomas EL, Mt-Isa S, Ashby D, Gibson GR, Kolida S, Dhillo WS, Bloom SR, Morley W, Clegg S, Frost G. Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Gut 2014; 307913
Gale C, Logan KM, Jeffries S, Parkinson JRC, Santhakumaran S, Uthaya S, Durighel G, Alavi A, Thomas EL, Bell JD, Modi N. Sexual dimorphism in relation to adipose tissue and intra-hepatocellular lipid deposition in early infancy. Int J Obes  2015; 39:629-32
Sam A H, Sleeth ML, Thomas EL, Ismail NA, Daud NM, Chambers E, Shojaee-Moradie F, Umpleby AM, Goldstone AP, Le Roux CW, Busbridge M, Laurie R, Cuthbertson DJ, Ghatei1 MA, Bloom SR, Frost GS, Bell JD, Murphy KG. Circulating pancreatic polypeptide concentrations predict visceral and liver fat content. JCEM 2015; 100:1048-52.
Guess N, Dornhorst A, Oliver N, Bell JD, Thomas EL, Frost G. A randomized controlled trial: The effect of inulin on weight management and ectopic fat in subjects with diabetes. Nutrition & Metabolism 2015; Oct 24. doi: 10.1186/s12986-015-0033-2
Borga M, Thomas El, Romu T, Rosander J, Fitzpatrick J, Dahlqvist-Leinhard O, Bell JD. Validation of a Fast Method for Quantification of Intra-abdominal and Subcutaneous Adipose Tissue for Large Scale Human Studies. NMR in Biomed 2015; 28:1747-1753
Cuthbertson DJ, Shojaee-Moradie F, Sprung VS, Jones H, Pugh CJ, Richardson P, Kemp GJ, Barrett M, Jackson NC, Thomas EL, Bell JD. Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homeostasis in obese patients with Non-Alcoholic Fatty Liver Disease. Clin Sci 2016; 130:93-104
Comninos AN, Anastasovska J, Sahuri-Arisoylu M, Li X, Li S, Hu M, Jayasena CN, Ghatei MA, Bloom SR, Matthews PM, O'Byrne KT, Bell JD, Dhillo WS. Kisspeptin signalling in the amygdala modulates reproductive hormone secretion. Brain Struct Funct (in press)
Goldstone AP, Miras A, Scholtz S, Jackson S, Neff K, Penicaud L, Geogheg J, Chhina N, Durighel G, Bell JD, Meillon S, Leroux C. Link between increased satiety gut hormones and reduced food reward following gastric bypass surgery for obesity. JCEM (in press)
Meienberg F, Yee M, Johnston D, Cox J, Robinson S, Bell JD Thomas EL, Taylor-Robinson SD, Godsland I. Liver fat in adults with GH deficiency: comparison to matched controls and the effect of GH replacement. Clin Endocr (in press)


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