Cancer Research Group

Publications

Publications

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Conjugation of quantum dots on carbon nanotubes for medical diagnosis and treatment.Madani, S.Y., Shabani, F., Dwek, M.V., Seifalian, A. M. International Journal of Nanomedicine, (2013) 8: 941-50

The DietCompLyf study: A prospective cohort study of breast cancer survival and phytoestrogen consumption. Ruth Swann, Annie Perkins, Louiza Velentzis, Cristian Ciria, Susan Dutton, Angela Mulligan, Jayne Woodside, Marie Cantwell, Anthony Leathem, Claire Robertson, Miriam Dwek. (2013) Maturitas 75 (3): 232-40.

A targeted glycoproteomic approach identifies cadherin-5 as a novel biomarker of metastatic breast cancer. Simon Fry, John Sinclair, John Timms, Anthony Leathem, Miriam Dwek; Cancer Letters Volume 328, Issue 2, 28 January 2013, Pages 335–344.

Lymphoedema Following Treatment for Breast Cancer. M Dharini, M Kulendren, M. V. Dwek, M Griffiths. Diseases (2012) 7(4) p108

A New Generation of Cell-Biosensors. Innovations in Pharmaceutical Technology (2012) Dwek MV and Aastrup T., Issue 40, p44-47

The DietCompLyf Study – a Prospective Longitudinal Study of Breast Cancer Survival. Swann, R.; Perkins, A.; Velentzis, L.; Mulligan, A.; Woodside, J.; Cantwell, M.; Dutton, S.; Leathem, A.; Robertson, C.; Dwek, M; (2012); European Journal of Cancervol. 48 July, 2012. p. S216. Abstract number 893.

DietCompLyf Study – a Multi-centre UK Study on Breast Cancer – What Are the Dietary and Lifestyle Changes Following Diagnosis? Perkins, K.A.; Swann, R.; Woodside, J.; Robertson, C.; Dutton, S.; Mulligan, A.; Velentzis, L.; Keshtgar, M.; Leathem, A.; Dwek, M; (2012); European Journal of Cancer vol. 48 July, 2012. p. S282. Abstract number 1171.

Identification of Metastasis-associated Glycoproteins in Colorectal Cancer. Peiris, D.; Markiv, A.; Curley, P.; Dwek, M; (2012); European Journal of Cancer vol. 48 July, 2012. p. S39-S40. Abstract number 163

Lectin array based strategies for identifying Metastasis-Associated changes in Glycosylation.  Simon Fry, Babak Afrough, Anthony Leathem and Miriam Dwek; (2012); Methods in Molecular Biology. Vol.878. pp 267-272.

2DE- based proteomics for the analysis of metastasis associated proteins. Metastasis Research Protocols. Miriam Dwek and Diluka Peiris; (2012);  Methods in Molecular Biology. Vol.878. pp.111-120.

Functionalization of single-walled carbon nanotubes and their binding to cancer cells. S. Y. Madani, A. Tan, M. V. Dwek, A. M. Seifalian; International Journal of Nanomedicine (2012) 7:1-10  http://www.dovepress.com/ 

 
A novel approach to determining the affinity of protein-carbohydrate interactions employing adherent cancer cells grown on a biosensor surface. D. Peiris, A. Markiv, G. P. Curley, M. V. Dwek (2012) Biosensors and Bioelectronics
 
Beyond the genome and proteome: targeting protein modifications in cancer.  A. Markiv; N. D. S. Rambaruth; M. V. Dwek  (2012) Current Opinions in Pharmacology.

19p13.1 is a triple negative-specific breast cancer susceptibility locus. Stevens KN, Fredericksen Z, Vachon CM, Wang X, Margolin S, Lindblom A, Nevanlinna H, Greco D, Aittomäki K, Blomqvist C, Chang-Claude J, Vrieling A, Flesch-Janys D, Sinn HP, Wang-Gohrke S, Nickels S, Brauch H; on behalf of the GENICA Network, Ko YD, Fischer HP, Schmutzler RK, Meindl A, Bartram CR, Schott S, Engel C, Godwin AK, Weaver J, Pathak HB, Sharma P, Brenner H, Müller H, Arndt V, Stegmaier C, Miron P, Yannoukakos D, Stavropoulou A, Fountzilas G, Gogas HJ, Swann R, Dwek M, Perkins A, Milne RL, Benítez J, Zamora MP, Pérez JI, Bojesen SE, Nielsen SF, Nordestgaard BG, Flyger H, Guénel P, Truong T, Menegaux F, Cordina-Duverger E, Burwinkel B, Marmé F, Schneeweiss A, Sohn C, Sawyer E, Tomlinson I, Kerin MJ, Peto J, Johnson N, Fletcher O, Dos Santos Silva I, Fasching PA, Beckmann MW, Hartmann A, Ekici AB, Lophatananon A, Muir K, Puttawibul P, Wiangnon S, Schmidt MK, Broeks A, Braaf LM, Rosenberg EH, Hopper JL, Apicella C, Park DJ, Southey MC, Swerdlow AJ, Ashworth A, Orr N, Schoemaker MJ, Anton-Culver H, Ziogas A, Bernstein L, Dur CC, Shen CY, Yu JC, Hsu HM, Hsiung CN, Hamann U, Dünnebier T, Rüdiger T, Ulmer HU, Pharoah PP, Dunning AM, Humphreys MK, Wang Q, Cox A, Cross SS, Reed MW, Hall P, Czene K, Ambrosone CB, Ademuyiwa F, Hwang H, Eccles DM, Garcia-Closas M, Figueroa JD, Sherman ME, Lissowska J, Devilee P, Seynaeve C, Tollenaar RA, Hooning MJ, Andrulis IL, Knight JA, Glendon G, Mulligan AM, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M, John EM, Miron A, Alnæs GG, Kristensen V, Børresen-Dale AL, Giles GG, Baglietto L, McLean CA, Severi G, Kosel ML, Pankratz VS, Slager S, Olson JE, Radice P, Peterlongo P, Manoukian S, Barile M, Lambrechts D, Hatse S, Dieudonne AS, Christiaens MR, Chenevix-Trench G; on behalf of kConFab Investigators; and the AOCS Group, Beesley J, Chen X, Mannermaa A, Kosma VM, Hartikainen JM, Soini Y, Easton DF, Couch FJ; (2012);  Cancer Res. 72 (7) 1795-1803.

Genome-wide association analysis identifies three new breast cancer susceptibility loci.Ghoussaini M, Fletcher O, Michailidou K, Turnbull C, Schmidt MK, Dicks E, Dennis J, Wang Q, Humphreys MK, Luccarini C, Baynes C, Conroy D, Maranian M, Ahmed S, Driver K, Johnson N, Orr N, dos Santos Silva I, Waisfisz Q, Meijers-Heijboer H, Uitterlinden AG, Rivadeneira F; Netherlands Collaborative Group on Hereditary Breast and Ovarian Cancer (HEBON), Hall P, Czene K, Irwanto A, Liu J, Nevanlinna H, Aittomäki K, Blomqvist C, Meindl A, Schmutzler RK, Müller-Myhsok B, Lichtner P, Chang-Claude J, Hein R, Nickels S, Flesch-Janys D, Tsimiklis H, Makalic E, Schmidt D, Bui M, Hopper JL, Apicella C, Park DJ, Southey M, Hunter DJ, Chanock SJ, Broeks A, Verhoef S, Hogervorst FB, Fasching PA, Lux MP, Beckmann MW, Ekici AB, Sawyer E, Tomlinson I, Kerin M, Marme F, Schneeweiss A, Sohn C, Burwinkel B, Guénel P, Truong T, Cordina-Duverger E, Menegaux F, Bojesen SE, Nordestgaard BG, Nielsen SF, Flyger H, Milne RL, Alonso MR, González-Neira A, Benítez J, Anton-Culver H, Ziogas A, Bernstein L, Dur CC, Brenner H, Müller H, Arndt V, Stegmaier C; Familial Breast Cancer Study (FBCS), Justenhoven C, Brauch H, Brüning T; Gene Environment Interaction of Breast Cancer in Germany (GENICA) Network, Wang-Gohrke S, Eilber U, Dörk T, Schürmann P, Bremer M, Hillemanns P, Bogdanova NV, Antonenkova NN, Rogov YI, Karstens JH, Bermisheva M, Prokofieva D, Khusnutdinova E, Lindblom A, Margolin S, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, Lambrechts D, Yesilyurt BT, Floris G, Leunen K, Manoukian S, Bonanni B, Fortuzzi S, Peterlongo P, Couch FJ, Wang X, Stevens K, Lee A, Giles GG, Baglietto L, Severi G, McLean C, Alnaes GG, Kristensen V, Børrensen-Dale AL, John EM, Miron A, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Kauppila S, Andrulis IL, Glendon G, Mulligan AM, Devilee P, van Asperen CJ, Tollenaar RA, Seynaeve C, Figueroa JD, Garcia-Closas M, Brinton L, Lissowska J, Hooning MJ, Hollestelle A, Oldenburg RA, van den Ouweland AM, Cox A, Reed MW, Shah M, Jakubowska A, Lubinski J, Jaworska K, Durda K, Jones M, Schoemaker M, Ashworth A, Swerdlow A, Beesley J, Chen X; kConFab Investigators; Australian Ovarian Cancer Study Group, Muir KR, Lophatananon A, Rattanamongkongul S, Chaiwerawattana A, Kang D, Yoo KY, Noh DY, Shen CY, Yu JC, Wu PE, Hsiung CN, Perkins A, Swann R, Velentzis L, Eccles DM, Tapper WJ, Gerty SM, Graham NJ, Ponder BA, Chenevix-Trench G, Pharoah PD, Lathrop M, Dunning AM, Rahman N, Peto J, Easton DF; (2012);  Nature Genetics 44 (3) 312-318

A physiological approach to assess the affinity of lectin carbohydrate interactions using cancer cells immobilised on a biosensor surface. Diluka Peiris, Anatoliy Markiv and Miriam Dwek; (2011);Society for Glycobiology meeting, Seattle, 2011, Abstract 222 published in Glycobiology 21 (11), page 1523.

Lectin microarray profiling of metastatic breast cancers.  Simon Fry, Babak Afrough, Hannah Lomax-Browne, John Timms, Louiza Velentzis, Miriam Dwek; (2011); 7th NCRI Cancer Conference, Liverpool, 6-9 November 2011.

DietCompLyf : An NCRN adopted observational prospective multi-centre study undertaken to investigate the effect that diet and lifestyle particularly phyto-nutrient intake has on the rates of recurrence and 5 year survival of women diagnosed with primary breast cancer. Annie Perkins, Ruth Swann, Sally Hughes, Tony Leathem, Claire Robertson, Susan Dutton, Jayne Woodside, Miriam Dwek; (2011);  7th NCRI Cancer Conference, Liverpool, 6-9 November 2011.

Identification cloning and characterization of two N-acetylgalactosamine binding lectins from the albumen gland of Helix pomatia. Anatoliy Markiv, Diluka Peiris, Paul Curley, Mark Odell and Miriam Dwek; (2011); Journal of Biological Chemistry DOI: 10.1074/jbc.M110.184515.

Lectin Microarray Profiling of Metastatic Breast Cancers. Simon Fry, Babak Afrough, Hannah Lomax-Browne, John Timms, Louisa Velentzis and Anthony Leathem (2011); Glycobiology. Apr 19. [Epub ahead of print]

Significant changes in dietary intake and supplement use after breast cancer diagnosis in a UK multicentre study. Louisa Velentzis, Mo Keshtgar, Jayne Woodside, Anthony Leathem, Ann Titcomb, Katherine Perkins et al Breast Cancer Res Treat. (2011) Jan 11. [Epub ahead of print]

Cell surface glycan-lectin interactions in tumor metastasis.Neela Rambaruth and Miriam Dwek; Acta Histochemica (2011) 113: p591– 600.

Molecular Interactions in Cancer Cell Metastasis. Susan Brooks, Hannah Lomax-Browne, et alActa Histochemica (2010).112(1): p3-25.

Breast cancer invasion is mediated by beta-N-acetylglucosaminidase (beta-NAG) and associated with a dysregulation in the secretory pathway of cancer cells. Kushen Ramessur, Pamela Greenwell, Robert Nash and Miriam Dwek; (2010); British Journal of Biomedical Science; 67 (4): p189-196

A sensitive assay to measure biomarker glycosylation demonstrates increased fucosylation of prostate specific antigen (PSA) in patients with prostate cancer compared with benign prostatic hyperplasia. Miriam Dwek, Andrew Jenks and Anthony Leathem, Clinica Chimica Acta (2010) 411 (23-24): p1935-1939

Vascular Endothelial Growth Factor Receptors VEGFR-2 and VEGFR-3 are localised primarily to vasculature in human primary solid cancers. Smith NR, Baker D, James N, Ratcliffe K, Ashton S, Sproat G, Swann R, Gray N, Ryan A, Jurgensmeier J, Womack C. (2010) Clinical Cancer Research 16 (14): p3548-61

Molecular Interactions in Cancer Cell Metastasis.Brooks, S. A., Lomax-Browne, H. J., Carter, T. M., Kinch, C. E. and Hall, D. M. S. (2010). Acta Histochemica. 112(1): p3-25.

Pre-2010

UEA-1 enables discrimination between prostate specific antigen from patients with prostate cancer and benign prostatic hyperplasia. Dwek, Miriam and Jenks, Andrew and Leathem, Anthony (2009) Glycobiology, 19 (11). p. 1318.

Cancer prognostication using a recombinant form of the lectin from Helix pomatia agglutinin. Dwek, Miriam and Markiv, Anatoly and Odell, Mark (2009) Glycobiology, 19 (11). p. 1318

Altered cell surface glycosylation functions in mechanisms of cancer cell metastasis. Susan Brooks, Hannah Lomax-Browne et al (2009). Anadolu University Journal of Science and Technology.10 (1): p91-101

Altered glycosylation of proteins in cancer: what is the potential for new anti-tumour strategies.

Brooks SA, Carter TM, Royle L, Harvey DJ, Fry SA, Kinch C, Dwek RA, Rudd PM. (2008) Anticancer Agents Med Chem; 8(1): p2-21.

Proteome analysis of metastatic colorectal cancer cells recognized by the lectin Helix pomatia agglutinin (HPA). Saint-Guirons J., Zeqiraj E., Schumacher U., Greenwell P., Dwek MV. (2007) Proteomics - Clinical Applications. 9: (22) p4082-9

Identification and elimination of false-positives in an ELISA-based system for qualitative assessment of glycoconjugate binding using a selection of plant lectins. Afrough B., Dwek MV, Greenwell P. (2007); Biotechniques. 43(4): p458-462

Predictors of axillary lymph node metastasis in breast cancer: a systematic review. Patani, N.R., Dwek, Miriam and Douek, M. (2007) European Journal of Surgical Oncology, 33 (4). pp. 409-419.

Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3.

Fry SA, Van den Steen PE, Royle L, Wormald MR, Leathem AJ, Opdenakker G, McDonnell JM, Dwek RA, Rudd PM. (2006) Biochemistry. 45(51): p15249-58.

The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors. Van den Steen PE, Van Aelst I, Hvidberg V, Piccard H, Fiten P, Jacobsen C, Moestrup SK, Fry S, Royle L, Wormald MR, Wallis R, Rudd PM, Dwek RA, Opdenakker G. (2006) J Biol Chem; 281(27): p18626-37.

A proteomic approach to identify the integrins α 6 and α V as HPA binding partners in the metastatic colorectal cancer cell line HT29. Saint-Guirons, Julien and Zeqiraj, Elton and Greenwell, Pamela and Dwek, Miriam (2006) Molecular and Cellular Proteomics, 5 (10 (supplement)). S148.

Glycoproteomics. Dwek, Miriam (2005) In: Redei, George P., (ed.) Encyclopedic dictionary of genetics, genomics, and proteomics. 2nd edition. Wiley-Liss, Hoboken, USA.

Structure/function of N-glycans. Dwek, Miriam (2005) In: Redei, George P., (ed.) Encyclopedic dictionary of genetics, genomics, and proteomics. 2nd edition. Wiley-Liss, Hoboken, USA.

The metabolic role of methymalonyl CoA mutase in Escherichia coli. Kannan, S.M. and Dwek, Miriam and Bucke, Christopher and Roy, Ipsita (2005) In: Proceedings of Viteomics: structure and function of vitamins and cofactors, 2005, Cambridge, UK

Confocal microscopy for the identification of glycosylation changes associated with metastatic colorectal cancer. Zeqiraj, Elton and Saint-Guirons, Julien and Kerrigan, Mark J.P. and Dwek, Miriam (2005) In: The Molecular Biology of Colorectal Cancer, 10 - 11 Mar 2005, UBHT Education Centre, Bristol, UK

Pre-2005

Harnessing changes in cellular glycosylation in new cancer treatment strategies. Dwek, Miriam and Brooks, Susan (2004) Current Cancer Drug Targets, 4 (5). pp. 425-442.

Breast cancer proteomics using 2-dimensional gel electrophoresis. Rawlings, S. and Dwek, Miriam (2004) In: Brooks, Susan and Harris, Adrian, (eds.) Breast cancer research protocols. Methods in molecular medicine (120: 1543-1894).

Proteome analysis enables separate clustering of normal breast, benign breast and breast cancer tissues. M. V. Dwek and A. Alaiya, (2003); British Journal of Cancer; 89: p305-307

Structure/function of N-glycans. Brooks, Susan and Dwek, Miriam (2003) In: Redei, George P., (ed.) Encyclopedic dictionary of genetics, genomics, and proteomics. John Wiley & Sons, Chichester, UK.

Glycoproteomics. Dwek, Miriam and Mills, P. (2003) In: Redei, George P., (ed.) Encyclopedic dictionary of genetics, genomics, and proteomics. John Wiley & Sons, Chichester, UK.

Use of proteomic methodology for the characterization of human milk fat globular membrane proteins. J. Charlwood, S. Hanrahan, R. Tyldesley, J. Langridge, M. V. Dwek, P. Camilleri. (2002) Analytical Biochemistry; 301: p314-324

Current perspectives in cancer proteomics. Dwek, Miriam and Rawlings, S. (2002) Molecular Biotechnology, 22 (2). p. 139-152.

Proteome and glycosylation mapping identifies post-translational modifications associated with aggressive breast cancer. Dwek, Miriam and Ross, Heidi and Leathem, Anthony (2001) Proteomics, 1 (6). p 756-63

Helix pomatia agglutinin lectin-binding oligosaccharides of aggressive breast cancer. M. V. Dwek, H. Ross, S. Streets, S. A. Brooks et al (2001)  Int. Journal of Cancer 95: p79-85

PRE-2000

A Detailed Analysis of Neutral and Acidic Carbohydrates in Human Milk. J. Charlwood, D. Tolson, M. Dwek, P. Camilleri, (1999); Analytical Biochemistry 273: p261-277

Release and Analysis of Polypeptides From Paraffin Wax Embedded Archival Tissues. S. A. Brooks, M. V. Dwek, A. J. C. Leathem, (1998) Histochemical Journal 30: p1-7

Breast Cancer Progression is Associated with a Reduction in the Diversity of Sialylated and Neutral Oligosaccharides. M. V. Dwek, H. A. Lacey, A. J. C. Leathem, (1998) Clinica Chimica Acta 242: p191-202

Oligosaccharide Release from Frozen and Paraffin-Wax Embedded Archival Tissues.

M. V. Dwek, S.A. Brooks, A.J.C. Streets, D.J. Harvey, A. J. C. Leathem, (1996) Analytical Biochemistry 242: p8-14

Identification, Purification and Analysis of a 55 kDa Lectin Binding Glycoprotein Present in Breast Cancer Tissue. A.J. Streets, S.A. Brooks, M.V. Dwek, A.J. Leathem, (1996) Clinica Chimica Acta 254: p47–61

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