After graduating from the University of Westminster with a BSc (Hon) Bioscience degree, I studied for a MSc in Pharmacology at Kings College London. My project (supervised by Dr Philip K. Moore) was the first to identify the novel nitric oxide synthase inhibitor L-NOARG and this work was subsequently published in the British Journal of Pharmacology. I then took up a PhD studentship at Kings College London (Physiology) under the supervision of Dr David Sugden, working on the characterisation of the receptors for the pineal hormone melatonin. My postdoctoral post at the Institute of Psychiatry (London), with Drs Clive Coen, Iain C. Campbell and John F. Powell, worked on the initial identification of circadian clock genes in the brain. Thereafter I became a Fogarty Visiting Fellow at the National Institutes of Health (USA), working with Dr David Klein on the first molecular characterisation of the limiting enzyme in melatonin synthesis. I continued to examine the pineal clock system as a Vice Chancellor fellow at the University of Surrey before taking up a Lectureship at the University of Leicester, where I focused on the molecular basis of cardiac function and circadian biology.
I have now come full circle and back to my home town London and back to Westminster (2013) where it all began, and this is rather exciting for me. I am very much looking forward to working with my colleagues on many diverse projects including circadian and cardiac biology.
I have led modules at level 5 to 7 and currently module leader for level 6 Advanced Pharmacology and Toxicology. I teach across Departments in several degrees at level 4 to 6. I supervise approximately 6 to 8 BSc laboratory projects each year, including MSc students.
Using a systems approach (molecular, cell, organ and animal models), our focus is to identify and delineate novel gene regulatory networks in cardiac function and define molecular mechanisms that control the expression of these genes critical to human health i.e. how does the circadian clock work, and how it impinges diverse biological processes in the heart?
Current research projects
- The role and mechanism of the circadian timing system (clock genes, pineal hormone melatonin) on cardiac function and disease
- Mechanisms of regulation and action of the muscle-enriched gene, Actin-binding Rho-activating protein (Abra), in biology and disease
Individuals that can self-fund and are interested in PhD projects on circadian biology and cardiac function and disease can contact me directly.